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(D-Ser2)Oxm[mPEG-PAL]
- Development stage
- Preclinical
- Lead developer
- Ulster University
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
(D-Ser2)Oxm[mPEG-PAL] is a novel, chemically modified, enzyme-resistant analogue of the gut hormone oxyntomodulin (Oxm). Developed by researchers at Ulster University and its spin-out company, Dia Beta Labs, the peptide is designed for the treatment of obesity and type 2 diabetes. It features a D-serine substitution at position 2 to confer resistance against dipeptidyl peptidase-IV (DPP-IV) degradation, and is PEGylated with a mini-polyethylene glycol (mPEG) linker conjugated to a palmitic acid (PAL) chain at the C-terminus to extend its circulating half-life. As a dual agonist of both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR), (D-Ser2)Oxm[mPEG-PAL] stimulates insulin secretion, improves glucose tolerance, reduces food intake, and promotes weight loss.
- Other names
- (D-Ser2)Oxm(mPEG-PAL)(D-Ser2)oxyntomodulin[mPEG-PAL](d-Ser(2))Oxm[mPEG-PAL](d-Ser2)Oxm[mPEG-PAL]
02
Targets
GCGR (Glucagon receptor)GLP1R (GLP-1R)
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